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  <xsd:element name="ScheduleOfLiquidityLineItems" id="nrxp_ScheduleOfLiquidityLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" />
  <xsd:element name="ScheduleOfLiquidityTable" id="nrxp_ScheduleOfLiquidityTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" />
  <xsd:element name="ScheduleOfWarrantsOrRightsValuationAssumptionsTableTextBlock" id="nrxp_ScheduleOfWarrantsOrRightsValuationAssumptionsTableTextBlock" type="dtr-types:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" />
  <xsd:element id="nrxp_SettlementExpense" name="SettlementExpense" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="nrxp_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsIntrinsicValueAbstract" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsIntrinsicValueAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValueForfeited" id="nrxp_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValueForfeited" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValueGranted" id="nrxp_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValueGranted" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2Granted" id="nrxp_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2Granted" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" />
  <xsd:element name="SponsoredResearchAgreementMember" id="nrxp_SponsoredResearchAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" />
  <xsd:element name="StockholdersEquityLineItems" id="nrxp_StockholdersEquityLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" />
  <xsd:element name="SummaryOfSignificantAccountingPoliciesAbstract" id="nrxp_SummaryOfSignificantAccountingPoliciesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" />
  <xsd:element name="TwoThousandAndEighteenNoteMember" id="nrxp_TwoThousandAndEighteenNoteMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" />
  <xsd:element name="TwoThousandAnsSeventeenConvertibleNotesMember" id="nrxp_TwoThousandAnsSeventeenConvertibleNotesMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" />
  <xsd:element name="TwoThousandEighteenConvertibleNotesPayableMember" id="nrxp_TwoThousandEighteenConvertibleNotesPayableMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" />
  <xsd:element name="TwoThousandSeventeenAndEighteenConvertibleNotesPayableMember" id="nrxp_TwoThousandSeventeenAndEighteenConvertibleNotesPayableMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" />
  <xsd:element name="TwoThousandSeventeenOmnibusPlanMember" id="nrxp_TwoThousandSeventeenOmnibusPlanMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" />
  <xsd:element name="WarrantExercisePrice" id="nrxp_WarrantExercisePrice" type="dtr-types:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" />
  <xsd:element name="WarrantsExpirationPeriod" id="nrxp_WarrantsExpirationPeriod" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" />
  <xsd:element name="WarrantsIssuedDuringPeriod" id="nrxp_WarrantsIssuedDuringPeriod" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" />
  <xsd:element id="nrxp_GainLossOnFairValueOfCashEarnOutLiability" name="GainLossOnFairValueOfCashEarnOutLiability" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="nrxp_StockRepurchasedDuringPeriodValueMergerAndRecapitalizationNetOfRedemptionsAndIssuanceCosts" name="StockRepurchasedDuringPeriodValueMergerAndRecapitalizationNetOfRedemptionsAndIssuanceCosts" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="nrxp_StockRepurchasedDuringPeriodSharesMergerAndRecapitalizationNetOfRedemptionsAndIssuanceCosts" name="StockRepurchasedDuringPeriodSharesMergerAndRecapitalizationNetOfRedemptionsAndIssuanceCosts" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_StockIssuedDuringPeriodValueNewIssuesFromPrivateInvesementInEquity" name="StockIssuedDuringPeriodValueNewIssuesFromPrivateInvesementInEquity" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="nrxp_AdjustmentsToAdditionalPaidInCapitalModificationsOfWarrantIssuedDueToBusinessCombination" name="AdjustmentsToAdditionalPaidInCapitalModificationsOfWarrantIssuedDueToBusinessCombination" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="nrxp_GainLossOnFairValueOfCashEarnoutLiability" name="GainLossOnFairValueOfCashEarnoutLiability" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="nrxp_ScheduleOfReconciliationOfMergerReverseRecapitalizationTableTextBlock" name="ScheduleOfReconciliationOfMergerReverseRecapitalizationTableTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_MergerAgreementWithMergerSubAndNeurorxMember" name="MergerAgreementWithMergerSubAndNeurorxMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_StockholdersOfNeurorxMember" name="StockholdersOfNeurorxMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_SubscriptionAgreementsMember" name="SubscriptionAgreementsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_BusinessCombinationContingentConsiderationPayableEarnoutShares" name="BusinessCombinationContingentConsiderationPayableEarnoutShares" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="nrxp_BusinessCombinationContingentConsiderationPayableInCash" name="BusinessCombinationContingentConsiderationPayableInCash" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="nrxp_BusinessCombinationCashHeldInTrustUsedForFundingNetOfRedemption" name="BusinessCombinationCashHeldInTrustUsedForFundingNetOfRedemption" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <xsd:element id="nrxp_BusinessCombinationRecognizedIdentifiableAssetsAcquiredNetWorkingCapitalAssumed" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredNetWorkingCapitalAssumed" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="nrxp_NetEquityImpactOfMerger" name="NetEquityImpactOfMerger" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="nrxp_BigRockPartnersAcquisitionFounderAndPrivateShareholdersMember" name="BigRockPartnersAcquisitionFounderAndPrivateShareholdersMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_BusinessCombinationSharesOutstandingOfAcquireePriorToConsummationOfMerger" name="BusinessCombinationSharesOutstandingOfAcquireePriorToConsummationOfMerger" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="nrxp_BusinessCombinationSharesOutstandingOfAcquireeNetOfRedemptions" name="BusinessCombinationSharesOutstandingOfAcquireeNetOfRedemptions" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="nrxp_SharesIssuedConversionOfAcquireeEntityRights" name="SharesIssuedConversionOfAcquireeEntityRights" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_CommonStockSharesIssuedThroughExchangeRatioImmediatelyAfterConsummationOfMerger" name="CommonStockSharesIssuedThroughExchangeRatioImmediatelyAfterConsummationOfMerger" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_BusinessCombinationSharesConvertedAtExchangeRatioImmediatelyAfterConsummationOfMerger" name="BusinessCombinationSharesConvertedAtExchangeRatioImmediatelyAfterConsummationOfMerger" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="nrxp_BusinessAcquisitionNumberOfSharesForfeited" name="BusinessAcquisitionNumberOfSharesForfeited" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_DisclosureOfPrepaidExpensesAndOtherCurrentAssetsTextBlock" name="DisclosureOfPrepaidExpensesAndOtherCurrentAssetsTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_PrepaidManufacturingExpensesCurrent" name="PrepaidManufacturingExpensesCurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <xsd:element id="nrxp_OtherAccruedExpensesCurrent" name="OtherAccruedExpensesCurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="nrxp_AdjustmentsToAdditionalPaidInCapitalModificationsOfStockOptionsDueToBusinessCombination" name="AdjustmentsToAdditionalPaidInCapitalModificationsOfStockOptionsDueToBusinessCombination" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="nrxp_ScheduleOfWarrantLiabilityValuationAssumptionsTableTextBlock" name="ScheduleOfWarrantLiabilityValuationAssumptionsTableTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_FairValueOfWarrants" name="FairValueOfWarrants" nillable="true" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="nrxp_WarrantLiabilityFairValueAssumptionsRiskFreeInterestRate" name="WarrantLiabilityFairValueAssumptionsRiskFreeInterestRate" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_WarrantLiabilityFairValueAssumptionsExpectedVolatilityRate" name="WarrantLiabilityFairValueAssumptionsExpectedVolatilityRate" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_WarrantLiabilityFairValueAssumptionsExpectedTerm" name="WarrantLiabilityFairValueAssumptionsExpectedTerm" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_VestedStockOptionsMember" name="VestedStockOptionsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_UnvestedStockOptionsMember" name="UnvestedStockOptionsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_TwoThousandTwentyOneOmnibusPlanMember" name="TwoThousandTwentyOneOmnibusPlanMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_NotesPayableDisclosureTextBlock" name="NotesPayableDisclosureTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_LegacyWarrantsMember" name="LegacyWarrantsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_SubstituteWarrantsMember" name="SubstituteWarrantsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_PublicWarrantsMember" name="PublicWarrantsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightRedemptionPriceOfWarrantsOrRights" name="ClassOfWarrantOrRightRedemptionPriceOfWarrantsOrRights" nillable="true" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightMinimumThresholdWrittenNoticePeriodForRedemptionOfWarrants" name="ClassOfWarrantOrRightMinimumThresholdWrittenNoticePeriodForRedemptionOfWarrants" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightRedemptionOfWarrantsOrRightsStockPriceTrigger" name="ClassOfWarrantOrRightRedemptionOfWarrantsOrRightsStockPriceTrigger" nillable="true" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightRedemptionOfWarrantsOrRightsThresholdTradingDays" name="ClassOfWarrantOrRightRedemptionOfWarrantsOrRightsThresholdTradingDays" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_RedemptionPeriod" name="RedemptionPeriod" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_PlacementWarrantsMember" name="PlacementWarrantsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_NetEarningsPerShareBasicAndDilutedAbstract" name="NetEarningsPerShareBasicAndDilutedAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightNumberAbstract" name="ClassOfWarrantOrRightNumberAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_WarrantsExercisedDuringPeriod" name="WarrantsExercisedDuringPeriod" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightWeightedAverageRemainingTermAbstract" name="ClassOfWarrantOrRightWeightedAverageRemainingTermAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_NumberOfUnitsOutstanding" name="NumberOfUnitsOutstanding" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="nrxp_UnitPrice" name="UnitPrice" nillable="true" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="nrxp_AggregateExercisePrice" name="AggregateExercisePrice" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="nrxp_NumberOfSharesPerUnit" name="NumberOfSharesPerUnit" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_NumberOfWarrantsPerUnit" name="NumberOfWarrantsPerUnit" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_NumberOfSharesPerRight" name="NumberOfSharesPerRight" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_UnitExpirationTerm" name="UnitExpirationTerm" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_DemandRightTerm" name="DemandRightTerm" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_PiggyBackRightTerm" name="PiggyBackRightTerm" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_FractionalSharesIssuedUponConversionOfRights" name="FractionalSharesIssuedUponConversionOfRights" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_PublicRightMember" name="PublicRightMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_PlacementRightsMember" name="PlacementRightsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_WarrantLiabilityPolicyTextBlock" name="WarrantLiabilityPolicyTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_EarnoutSharesMember" name="EarnoutSharesMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightWeightedAverageExercisePriceAbstract" name="ClassOfWarrantOrRightWeightedAverageExercisePriceAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_DeemedDividendEarnoutShares" name="DeemedDividendEarnoutShares" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="nrxp_EquityUnitPurchaseAgreementsWarrantsMember" name="EquityUnitPurchaseAgreementsWarrantsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_EquityUnitPurchaseAgreementsPublicRightsMember" name="EquityUnitPurchaseAgreementsPublicRightsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightWeightedAverageRemainingContractualTerm" name="ClassOfWarrantOrRightWeightedAverageRemainingContractualTerm" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightsGrantInPeriodWeightedAverageRemainingContractualTerm" name="ClassOfWarrantOrRightsGrantInPeriodWeightedAverageRemainingContractualTerm" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRightsIssued" name="ClassOfWarrantOrRightExercisePriceOfWarrantsOrRightsIssued" nillable="true" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRightsAssumedExercised" name="ClassOfWarrantOrRightExercisePriceOfWarrantsOrRightsAssumedExercised" nillable="true" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightAggregateIntrinsicValueAbstract" name="ClassOfWarrantOrRightAggregateIntrinsicValueAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightOutstandingIntrinsicValue" name="ClassOfWarrantOrRightOutstandingIntrinsicValue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightGrantedIntrinsicValue" name="ClassOfWarrantOrRightGrantedIntrinsicValue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="nrxp_WarrantsExercisedAggregateIntrinsicValue" name="WarrantsExercisedAggregateIntrinsicValue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="nrxp_EarnoutCashLiabilityFairValueDisclosure" name="EarnoutCashLiabilityFairValueDisclosure" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="nrxp_EarnoutCashLiabilitiesMember" name="EarnoutCashLiabilitiesMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_EstimatedTradingPrice" name="EstimatedTradingPrice" nillable="true" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_StockIssuedDuringPeriodValueNewIssuesFromPrivateInvestmentInEquity" name="StockIssuedDuringPeriodValueNewIssuesFromPrivateInvestmentInEquity" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="nrxp_StockIssuedDuringPeriodSharesNewIssuesFromPrivateInvestmentInEquity" name="StockIssuedDuringPeriodSharesNewIssuesFromPrivateInvestmentInEquity" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_CommonStockFairValueOutstanding" name="CommonStockFairValueOutstanding" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="nrxp_OriginalOptionsMember" name="OriginalOptionsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_SubstituteOptionsMember" name="SubstituteOptionsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_NetOfRedemptionsAndIssuanceCosts" name="NetOfRedemptionsAndIssuanceCosts" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="nrxp_FinancingNetOfIssuanceCosts" name="FinancingNetOfIssuanceCosts" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="nrxp_NetImpactToAdditionalPaidInCapital" name="NetImpactToAdditionalPaidInCapital" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="nrxp_LegacyNeurorxPreferredStockMember" name="LegacyNeurorxPreferredStockMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_StockholdersEquityAsPreviouslyReported" name="StockholdersEquityAsPreviouslyReported" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="nrxp_SharesOutstandingAsPreviouslyReported" name="SharesOutstandingAsPreviouslyReported" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="nrxp_RetroactiveApplicationOfReverseRecapitalizationValue" name="RetroactiveApplicationOfReverseRecapitalizationValue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="nrxp_RetroactiveApplicationOfReverseRecapitalizationShares" name="RetroactiveApplicationOfReverseRecapitalizationShares" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="nrxp_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsBeforeReverseRecapitalization" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsBeforeReverseRecapitalization" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="nrxp_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsRetroactiveApplicationOfReverseRecapitalization" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsRetroactiveApplicationOfReverseRecapitalization" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="nrxp_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceBeforeReverseRecapitalization" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceBeforeReverseRecapitalization" nillable="true" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="nrxp_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRetroactiveApplicationOfReverseRecapitalization" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRetroactiveApplicationOfReverseRecapitalization" nillable="true" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="nrxp_ShareBasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2BeforeReverseRecapitalization" name="ShareBasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2BeforeReverseRecapitalization" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValueBeforeReverseRecapitalization" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValueBeforeReverseRecapitalization" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <xsd:element id="nrxp_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValueExercised" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValueExercised" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="nrxp_EffectOfMergerNetOfRedemptionsAndTransactionCostsRelatingToChangesOfCashFlows" name="EffectOfMergerNetOfRedemptionsAndTransactionCostsRelatingToChangesOfCashFlows" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="nrxp_AllocatedShareBasedCompensationExpenseExpectedToBeRecognizedInFuture" name="AllocatedShareBasedCompensationExpenseExpectedToBeRecognizedInFuture" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element name="ReclassificationOfWarrantsToWarrantLiability" id="nrxp_ReclassificationOfWarrantsToWarrantLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="RestatementOfBalanceSheetAbstract" id="nrxp_RestatementOfBalanceSheetAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RestatementOfStatementOfOperationsAbstract" id="nrxp_RestatementOfStatementOfOperationsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RestatementOfStatementOfStockholdersEquityAbstract" id="nrxp_RestatementOfStatementOfStockholdersEquityAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RestatementOfStatementOfCashFlowsAbstract" id="nrxp_RestatementOfStatementOfCashFlowsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SharesSubjectToMandatoryRedemptionLegacyWarrants" id="nrxp_SharesSubjectToMandatoryRedemptionLegacyWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ImpactOnDilutedNetIncomeLossFromWarrantsClassifiedUnderTreasuryStockMethod" id="nrxp_ImpactOnDilutedNetIncomeLossFromWarrantsClassifiedUnderTreasuryStockMethod" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="WeightedAverageSharesIncrementalEffectOfWarrantsClassifiedUnderTreasuryStockMethod" id="nrxp_WeightedAverageSharesIncrementalEffectOfWarrantsClassifiedUnderTreasuryStockMethod" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
</xsd:schema>
