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  <xsd:element id="nrxp_SubscriptionAgreementsMember" name="SubscriptionAgreementsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_BusinessCombinationContingentConsiderationPayableEarnoutShares" name="BusinessCombinationContingentConsiderationPayableEarnoutShares" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="nrxp_BusinessCombinationContingentConsiderationPayableInCash" name="BusinessCombinationContingentConsiderationPayableInCash" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="nrxp_BusinessCombinationCashHeldInTrustUsedForFundingNetOfRedemption" name="BusinessCombinationCashHeldInTrustUsedForFundingNetOfRedemption" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" abstract="false" />
  <xsd:element id="nrxp_BusinessCombinationRecognizedIdentifiableAssetsAcquiredNetWorkingCapitalAssumed" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredNetWorkingCapitalAssumed" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" abstract="false" />
  <xsd:element id="nrxp_BigRockPartnersAcquisitionFounderAndPrivateShareholdersMember" name="BigRockPartnersAcquisitionFounderAndPrivateShareholdersMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_BusinessCombinationSharesOutstandingOfAcquireePriorToConsummationOfMerger" name="BusinessCombinationSharesOutstandingOfAcquireePriorToConsummationOfMerger" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="nrxp_BusinessCombinationSharesOutstandingOfAcquireeNetOfRedemptions" name="BusinessCombinationSharesOutstandingOfAcquireeNetOfRedemptions" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="nrxp_SharesIssuedConversionOfAcquireeEntityRights" name="SharesIssuedConversionOfAcquireeEntityRights" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_CommonStockSharesIssuedThroughExchangeRatioImmediatelyAfterConsummationOfMerger" name="CommonStockSharesIssuedThroughExchangeRatioImmediatelyAfterConsummationOfMerger" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_BusinessCombinationSharesConvertedAtExchangeRatioImmediatelyAfterConsummationOfMerger" name="BusinessCombinationSharesConvertedAtExchangeRatioImmediatelyAfterConsummationOfMerger" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="nrxp_BusinessAcquisitionNumberOfSharesForfeited" name="BusinessAcquisitionNumberOfSharesForfeited" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_DisclosureOfPrepaidExpensesAndOtherCurrentAssetsTextBlock" name="DisclosureOfPrepaidExpensesAndOtherCurrentAssetsTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_PrepaidManufacturingExpensesCurrent" name="PrepaidManufacturingExpensesCurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <xsd:element id="nrxp_OtherAccruedExpensesCurrent" name="OtherAccruedExpensesCurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="nrxp_AdjustmentsToAdditionalPaidInCapitalModificationsOfStockOptionsDueToBusinessCombination" name="AdjustmentsToAdditionalPaidInCapitalModificationsOfStockOptionsDueToBusinessCombination" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="nrxp_ScheduleOfWarrantLiabilityValuationAssumptionsTableTextBlock" name="ScheduleOfWarrantLiabilityValuationAssumptionsTableTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_FairValueOfWarrants" name="FairValueOfWarrants" nillable="true" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="nrxp_WarrantLiabilityFairValueAssumptionsExpectedDividendRate" name="WarrantLiabilityFairValueAssumptionsExpectedDividendRate" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_WarrantLiabilityFairValueAssumptionsRiskFreeInterestRate" name="WarrantLiabilityFairValueAssumptionsRiskFreeInterestRate" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_WarrantLiabilityFairValueAssumptionsExpectedVolatilityRate" name="WarrantLiabilityFairValueAssumptionsExpectedVolatilityRate" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_WarrantLiabilityFairValueAssumptionsExpectedTerm" name="WarrantLiabilityFairValueAssumptionsExpectedTerm" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_StrikePrice" name="StrikePrice" nillable="true" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="nrxp_VestedStockOptionsMember" name="VestedStockOptionsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_TwoThousandTwentyOneOmnibusPlanMember" name="TwoThousandTwentyOneOmnibusPlanMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_LegacyWarrantsMember" name="LegacyWarrantsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_SubstituteWarrantsMember" name="SubstituteWarrantsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_PublicWarrantsMember" name="PublicWarrantsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightRedemptionPriceOfWarrantsOrRights" name="ClassOfWarrantOrRightRedemptionPriceOfWarrantsOrRights" nillable="true" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightMinimumThresholdWrittenNoticePeriodForRedemptionOfWarrants" name="ClassOfWarrantOrRightMinimumThresholdWrittenNoticePeriodForRedemptionOfWarrants" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightRedemptionOfWarrantsOrRightsStockPriceTrigger" name="ClassOfWarrantOrRightRedemptionOfWarrantsOrRightsStockPriceTrigger" nillable="true" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightRedemptionOfWarrantsOrRightsThresholdTradingDays" name="ClassOfWarrantOrRightRedemptionOfWarrantsOrRightsThresholdTradingDays" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_RedemptionPeriod" name="RedemptionPeriod" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_PlacementWarrantsMember" name="PlacementWarrantsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_NetEarningsPerShareBasicAndDilutedAbstract" name="NetEarningsPerShareBasicAndDilutedAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightNumberAbstract" name="ClassOfWarrantOrRightNumberAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightAssumed" name="ClassOfWarrantOrRightAssumed" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_WarrantsExercisedDuringPeriod" name="WarrantsExercisedDuringPeriod" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightWeightedAverageRemainingTermAbstract" name="ClassOfWarrantOrRightWeightedAverageRemainingTermAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_UnitPrice" name="UnitPrice" nillable="true" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="nrxp_WarrantLiabilityPolicyTextBlock" name="WarrantLiabilityPolicyTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_EarnoutSharesMember" name="EarnoutSharesMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightWeightedAverageExercisePriceAbstract" name="ClassOfWarrantOrRightWeightedAverageExercisePriceAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRightsCancelled" name="ClassOfWarrantOrRightExercisePriceOfWarrantsOrRightsCancelled" nillable="true" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_DeemedDividendWarrants" name="DeemedDividendWarrants" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightsGrantInPeriodWeightedAverageRemainingContractualTerm" name="ClassOfWarrantOrRightsGrantInPeriodWeightedAverageRemainingContractualTerm" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRightsIssued" name="ClassOfWarrantOrRightExercisePriceOfWarrantsOrRightsIssued" nillable="true" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRightsAssumed" name="ClassOfWarrantOrRightExercisePriceOfWarrantsOrRightsAssumed" nillable="true" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRightsAssumedExercised" name="ClassOfWarrantOrRightExercisePriceOfWarrantsOrRightsAssumedExercised" nillable="true" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightAggregateIntrinsicValueAbstract" name="ClassOfWarrantOrRightAggregateIntrinsicValueAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightOutstandingIntrinsicValue" name="ClassOfWarrantOrRightOutstandingIntrinsicValue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightGrantedIntrinsicValue" name="ClassOfWarrantOrRightGrantedIntrinsicValue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightAssumedIntrinsicValue" name="ClassOfWarrantOrRightAssumedIntrinsicValue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="nrxp_WarrantsExercisedAggregateIntrinsicValue" name="WarrantsExercisedAggregateIntrinsicValue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="nrxp_EarnoutCashLiabilityFairValueDisclosure" name="EarnoutCashLiabilityFairValueDisclosure" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="nrxp_EarnoutCashLiabilitiesMember" name="EarnoutCashLiabilitiesMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_StockIssuedDuringPeriodValueNewIssuesFromPrivateInvestmentInEquity" name="StockIssuedDuringPeriodValueNewIssuesFromPrivateInvestmentInEquity" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="nrxp_OriginalOptionsMember" name="OriginalOptionsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_SubstituteOptionsMember" name="SubstituteOptionsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_NetOfRedemptionsAndIssuanceCosts" name="NetOfRedemptionsAndIssuanceCosts" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="nrxp_FinancingNetOfIssuanceCosts" name="FinancingNetOfIssuanceCosts" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="nrxp_LegacyNeurorxPreferredStockMember" name="LegacyNeurorxPreferredStockMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightExercisePriceOfWarrantsBeforeReverseRecapitalization" name="ClassOfWarrantOrRightExercisePriceOfWarrantsBeforeReverseRecapitalization" nillable="true" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightExercisePriceOfWarrantsRetroactiveApplicationOfReverseRecapitalization" name="ClassOfWarrantOrRightExercisePriceOfWarrantsRetroactiveApplicationOfReverseRecapitalization" nillable="true" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightOutstandingIntrinsicValueBeforeReverseRecapitalization" name="ClassOfWarrantOrRightOutstandingIntrinsicValueBeforeReverseRecapitalization" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <xsd:element id="nrxp_OptionExchangeRatioSharesEarnoutSharesForCommonStockholders" name="OptionExchangeRatioSharesEarnoutSharesForCommonStockholders" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_OptionExchangeRatioValueEarnoutCashForCommonStockholders" name="OptionExchangeRatioValueEarnoutCashForCommonStockholders" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="nrxp_CommonStockAndWarrantsIssuedInPrivatePlacementNetOfIssuanceCosts" name="CommonStockAndWarrantsIssuedInPrivatePlacementNetOfIssuanceCosts" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="nrxp_CommonStockAndWarrantsIssuedInPrivatePlacementNumberOfShares" name="CommonStockAndWarrantsIssuedInPrivatePlacementNumberOfShares" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_IssuanceOfStockForExerciseOfWarrantsAndOption" name="IssuanceOfStockForExerciseOfWarrantsAndOption" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="nrxp_SharesOfStockIssuedForExerciseOfWarrantsAndOptions" name="SharesOfStockIssuedForExerciseOfWarrantsAndOptions" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_StockIssuedForPaymentOfConsultingServices" name="StockIssuedForPaymentOfConsultingServices" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="nrxp_SharesOfStockIssuedForPaymentOfConsultingServices" name="SharesOfStockIssuedForPaymentOfConsultingServices" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_SaleOfStockAndWarrantsIssuanceCosts" name="SaleOfStockAndWarrantsIssuanceCosts" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="nrxp_NetProceedsFromPaymentsForIssuanceOfCommonStockAndWarrantsInPrivatePlacementNetOfIssuanceCosts" name="NetProceedsFromPaymentsForIssuanceOfCommonStockAndWarrantsInPrivatePlacementNetOfIssuanceCosts" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="nrxp_PreferredInvestmentOptionsMember" name="PreferredInvestmentOptionsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_EarnoutSharesFromExercisedSubstituteOptionsAndSubstituteWarrantsMember" name="EarnoutSharesFromExercisedSubstituteOptionsAndSubstituteWarrantsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_PrepaidClinicalDevelopmentExpenses" name="PrepaidClinicalDevelopmentExpenses" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <xsd:element id="nrxp_ContingentEarnoutSharesExcludedFromEpsComputation" name="ContingentEarnoutSharesExcludedFromEpsComputation" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightForfeited" name="ClassOfWarrantOrRightForfeited" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_WarrantsCanceledOrForfeitedAggregateIntrinsicValue" name="WarrantsCanceledOrForfeitedAggregateIntrinsicValue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="nrxp_PilltrackerSowMember" name="PilltrackerSowMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_VaccinecoMember" name="VaccinecoMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ClassOfWarrantOrRightWeightedAverageRemainingContractualTerm2" name="ClassOfWarrantOrRightWeightedAverageRemainingContractualTerm2" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="nrxp_ShareBasedCompensationArrangementOptionsOutstandingWeightedAverageRemainingContractualTerm2" name="ShareBasedCompensationArrangementOptionsOutstandingWeightedAverageRemainingContractualTerm2" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element name="EffectiveIncomeTaxRateReconciliationSettlementWarrants" id="nrxp_EffectiveIncomeTaxRateReconciliationSettlementWarrants" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DeferredTaxLiabilitiesDepreciation" id="nrxp_DeferredTaxLiabilitiesDepreciation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="UnrecognizedTaxBenefitsDecreaseInDeferredTaxAsset" id="nrxp_UnrecognizedTaxBenefitsDecreaseInDeferredTaxAsset" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ProceedsFromIssuanceOfCommonStockAndExerciseOfStockOptions" id="nrxp_ProceedsFromIssuanceOfCommonStockAndExerciseOfStockOptions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="EffectiveIncomeTaxRateReconciliationFairMarketValueEarnout" id="nrxp_EffectiveIncomeTaxRateReconciliationFairMarketValueEarnout" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="WarrantsExpirationTerm" id="nrxp_WarrantsExpirationTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="FormerChiefExecutiveOfficerMember" id="nrxp_FormerChiefExecutiveOfficerMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CommonStockSharesIssuedNewIssuanceAndSaleOfOptionsAndWarrants" id="nrxp_CommonStockSharesIssuedNewIssuanceAndSaleOfOptionsAndWarrants" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ProceedsFromSaleOfStockNewIssuancesAndSaleOfStockOptionsAndWarrants" id="nrxp_ProceedsFromSaleOfStockNewIssuancesAndSaleOfStockOptionsAndWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ShareBasedCompensationArrangementPaymentAwardOptionsAggregateGranted" id="nrxp_ShareBasedCompensationArrangementPaymentAwardOptionsAggregateGranted" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="ProceedsFromRepaymentsOfNotesPayableAssumedInMerger" id="nrxp_ProceedsFromRepaymentsOfNotesPayableAssumedInMerger" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ReclassificationOfLegacyWarrantsToWarrantLiability" id="nrxp_ReclassificationOfLegacyWarrantsToWarrantLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="PrepaidLegalExpenses" id="nrxp_PrepaidLegalExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="PromissoryNote9RedeemableMember" id="nrxp_PromissoryNote9RedeemableMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="BusinessCombinationCashInflowPipeFinancingNetOfTransactionCosts" id="nrxp_BusinessCombinationCashInflowPipeFinancingNetOfTransactionCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="BusinessCombinationEffectOnEquityOfNotesPayableAssumed" id="nrxp_BusinessCombinationEffectOnEquityOfNotesPayableAssumed" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="BusinessCombinationEffectOnEquityOfPlacementWarrantsAssumed" id="nrxp_BusinessCombinationEffectOnEquityOfPlacementWarrantsAssumed" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="BusinessCombinationEffectOnEquityOfEarnoutCash" id="nrxp_BusinessCombinationEffectOnEquityOfEarnoutCash" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="IncreaseDecreaseInFairValueOfConvertibleDebt" id="nrxp_IncreaseDecreaseInFairValueOfConvertibleDebt" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="EarnoutStockRetiredDuringPeriodValue" id="nrxp_EarnoutStockRetiredDuringPeriodValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="EarnoutStockRetiredDuringPeriodShares" id="nrxp_EarnoutStockRetiredDuringPeriodShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="InvestorWarrantsMember" id="nrxp_InvestorWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ShareTransferLockInPeriod" id="nrxp_ShareTransferLockInPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="WarrantsAndRightsExercisableTerm" id="nrxp_WarrantsAndRightsExercisableTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="LongTermDebtBeforeFairValueAdjustments" id="nrxp_LongTermDebtBeforeFairValueAdjustments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="TwoThousandSixteenOmnibusPlanMember" id="nrxp_TwoThousandSixteenOmnibusPlanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="Dr.JonathanJavittMember" id="nrxp_Dr.JonathanJavittMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RestrictionsRemovedOnNewDrugApplicationDateMember" id="nrxp_RestrictionsRemovedOnNewDrugApplicationDateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RestrictionsRemovedOnNewDrugApprovalDateMember" id="nrxp_RestrictionsRemovedOnNewDrugApprovalDateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PaymentRateToRelatedPartyPerYear" id="nrxp_PaymentRateToRelatedPartyPerYear" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="PaymentRateToRelatedPartyPerMonth" id="nrxp_PaymentRateToRelatedPartyPerMonth" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="RelatedPartyMinimumPerformanceBasedAnnualBonus" id="nrxp_RelatedPartyMinimumPerformanceBasedAnnualBonus" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CollaborativeArrangementMilestonePaymentsReceivable" id="nrxp_CollaborativeArrangementMilestonePaymentsReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="CollaborativeArrangementRoyaltyPaymentsReceivable" id="nrxp_CollaborativeArrangementRoyaltyPaymentsReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="CollaborativeArrangementThresholdLiabilityForIndemnityClaims" id="nrxp_CollaborativeArrangementThresholdLiabilityForIndemnityClaims" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CollaborativeArrangementThresholdIndemnityObligationForBreachOfCovenantsAndOtherAgreements" id="nrxp_CollaborativeArrangementThresholdIndemnityObligationForBreachOfCovenantsAndOtherAgreements" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CollaborativeArrangementThresholdIndemnityObligationForBreachOfRepresentationsAndWarranties" id="nrxp_CollaborativeArrangementThresholdIndemnityObligationForBreachOfRepresentationsAndWarranties" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DeferredTaxAssets174Capitalization" id="nrxp_DeferredTaxAssets174Capitalization" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ReliefTherapeuticsHoldingsAgMember" id="nrxp_ReliefTherapeuticsHoldingsAgMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ReliefTherapeuticsLawsuitMember" id="nrxp_ReliefTherapeuticsLawsuitMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsBeforeReverseRecapitalization" id="nrxp_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsBeforeReverseRecapitalization" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceBeforeReverseRecapitalization" id="nrxp_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceBeforeReverseRecapitalization" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="SharebasedcompensationarrangementbysharebasedpaymentawardoptionsoutstandingweightedAverageRemainingContractualTerm2BeforeReverseRecapitalization" id="nrxp_SharebasedcompensationarrangementbysharebasedpaymentawardoptionsoutstandingweightedAverageRemainingContractualTerm2BeforeReverseRecapitalization" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValueBeforeReverseRecapitalization" id="nrxp_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValueBeforeReverseRecapitalization" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsRetroactiveApplicationOfReverseRecapitalization" id="nrxp_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsRetroactiveApplicationOfReverseRecapitalization" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRetroactiveApplicationOfReverseRecapitalization" id="nrxp_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRetroactiveApplicationOfReverseRecapitalization" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValueExercised" id="nrxp_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValueExercised" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsWeightedAverageRemainingContractualTerm" id="nrxp_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsWeightedAverageRemainingContractualTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2Exercised" id="nrxp_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2Exercised" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ClassOfWarrantOrRightWeightedAverageRemainingContractualTermExpired" id="nrxp_ClassOfWarrantOrRightWeightedAverageRemainingContractualTermExpired" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ClassOfWarrantOrRightExpired" id="nrxp_ClassOfWarrantOrRightExpired" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ClassOfWarrantOrRightExercisePriceOfWarrantsOrRightsExpired" id="nrxp_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRightsExpired" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="StockIssuedDuringPeriodSharesNewIssuesFromPrivateInvestmentInEquity" id="nrxp_StockIssuedDuringPeriodSharesNewIssuesFromPrivateInvestmentInEquity" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTermForfeited" id="nrxp_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTermForfeited" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ClassOfWarrantOrRightsAssumedInPeriodWeightedAverageRemainingContractualTerm" id="nrxp_ClassOfWarrantOrRightsAssumedInPeriodWeightedAverageRemainingContractualTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="OptionAwardsPercentageOfOutstandingSharesUsedToDetermineAdditionalSharesAuthorizedVotingInterestsRetainedByShareholders" id="nrxp_OptionAwardsPercentageOfOutstandingSharesUsedToDetermineAdditionalSharesAuthorizedVotingInterestsRetainedByShareholders" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
</xsd:schema>
