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  <xsd:element name="TherapeuticProductNrx101Member" id="nrxp_TherapeuticProductNrx101Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ExclusiveGlobalDevelopmentSupplyMarketingLicenseAgreementMember" id="nrxp_ExclusiveGlobalDevelopmentSupplyMarketingLicenseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AlvogenPharmaUsInc.AlvogenInc.AndLotusPharmaceuticalCo.LtdMember" id="nrxp_AlvogenPharmaUsInc.AlvogenInc.AndLotusPharmaceuticalCo.LtdMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LicenseAgreementMinimumPeriodForEquitableRoyaltyPayableInCaseOfReversionLicense" id="nrxp_LicenseAgreementMinimumPeriodForEquitableRoyaltyPayableInCaseOfReversionLicense" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="InitialCashPaymentToBeReceived" id="nrxp_InitialCashPaymentToBeReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="SecondMilestonePaymentsReceivable" id="nrxp_SecondMilestonePaymentsReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="MaximumBonusMilestonePaymentsReceivable" id="nrxp_MaximumBonusMilestonePaymentsReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AlvogenLicensingAgreementTextBlock" id="nrxp_AlvogenLicensingAgreementTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="LetterAgreementPercentageOfCashFeePaid" id="nrxp_LetterAgreementPercentageOfCashFeePaid" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="LetterAgreementPaymentsOfCashFeeCredit" id="nrxp_LetterAgreementPaymentsOfCashFeeCredit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="SecuritiesPurchaseAgreementPlacementAgentFeePercentage" id="nrxp_SecuritiesPurchaseAgreementPlacementAgentFeePercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentRepaymentsOfPrincipal" id="nrxp_DebtInstrumentRepaymentsOfPrincipal" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="JunePlacementAgentWarrantsMember" id="nrxp_JunePlacementAgentWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AmendedWarrantsMember" id="nrxp_AmendedWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="MeasurementInputFairValuePerShareMember" id="nrxp_MeasurementInputFairValuePerShareMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="WarrantsFairValueDisclosure" id="nrxp_WarrantsFairValueDisclosure" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="JuneInvestorAmendedWarrantsMember" id="nrxp_JuneInvestorAmendedWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="H.c.WainwrightCo.LlcMember" id="nrxp_H.c.WainwrightCo.LlcMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LicenseAgreementThresholdAggregateLiquidity" id="nrxp_LicenseAgreementThresholdAggregateLiquidity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="RelatedPartyTransactionConsultingFeePayablePerMonth" id="nrxp_RelatedPartyTransactionConsultingFeePayablePerMonth" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="RelatedPartyTransactionsPerformanceBasedAnnualBonusMinimumTarget" id="nrxp_RelatedPartyTransactionsPerformanceBasedAnnualBonusMinimumTarget" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="NumberOfSharesRestrictionsRemovedOnNewDrugApplicationDate" id="nrxp_NumberOfSharesRestrictionsRemovedOnNewDrugApplicationDate" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="NumberOfSharesRestrictionsRemovedOnNewDrugApprovalDate" id="nrxp_NumberOfSharesRestrictionsRemovedOnNewDrugApprovalDate" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="AmendmentTwoMember" id="nrxp_AmendmentTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DefaultTriggerEventsMember" id="nrxp_DefaultTriggerEventsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SeriesConvertiblePreferredStockMember" id="nrxp_SeriesConvertiblePreferredStockMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ModificationOfWarrantsPolicyTextBlock" id="nrxp_ModificationOfWarrantsPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="StockIssuedDuringPeriodValueSettlementOfLiability" id="nrxp_StockIssuedDuringPeriodValueSettlementOfLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="StockIssuedDuringPeriodSharesSettlementOfLiability" id="nrxp_StockIssuedDuringPeriodSharesSettlementOfLiability" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="RepaymentsOfInsuranceLoan" id="nrxp_RepaymentsOfInsuranceLoan" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="SecuritiesPurchaseAgreementAugustInvestorsMember" id="nrxp_SecuritiesPurchaseAgreementAugustInvestorsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PreferredStockPolicyPolicyTextBlock" id="nrxp_PreferredStockPolicyPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentOriginalIssueDiscount" id="nrxp_DebtInstrumentOriginalIssueDiscount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DebtInstrumentPrepaymentAmountPayableAsPercentageOfPrincipalInterestAndFeesOwed" id="nrxp_DebtInstrumentPrepaymentAmountPayableAsPercentageOfPrincipalInterestAndFeesOwed" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="DebtInstrumentMaximumOutstandingBalanceThatCanBeRedeemedByHolderPerMonth" id="nrxp_DebtInstrumentMaximumOutstandingBalanceThatCanBeRedeemedByHolderPerMonth" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DebtInstrumentRedemptionPercentageOfPremiumPayableOnAmountRedeemedIfRedeemedInCash" id="nrxp_DebtInstrumentRedemptionPercentageOfPremiumPayableOnAmountRedeemedIfRedeemedInCash" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="DebtInstrumentRedemptionConversionPriceAsPercentageOfAverageLowestDailyVolumeWeightedAveragePricesPerShare" id="nrxp_DebtInstrumentRedemptionConversionPriceAsPercentageOfAverageLowestDailyVolumeWeightedAveragePricesPerShare" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentRedemptionConversionPriceNumberOfLowestDailyVolumeWeightedAveragePricesPerShareConsidered" id="nrxp_DebtInstrumentRedemptionConversionPriceNumberOfLowestDailyVolumeWeightedAveragePricesPerShareConsidered" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentRedemptionConversionPriceNumberOfTradingDaysConsidered" id="nrxp_DebtInstrumentRedemptionConversionPriceNumberOfTradingDaysConsidered" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentRedemptionTriggerMinimumPercentageOfDailyDollarTradingVolumeOfCommonStockConsidered" id="nrxp_DebtInstrumentRedemptionTriggerMinimumPercentageOfDailyDollarTradingVolumeOfCommonStockConsidered" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentRedemptionTriggerNumberOfPreviousTradingDaysOverWhichMedianDailyDollarTradingVolumeIsConsidered" id="nrxp_DebtInstrumentRedemptionTriggerNumberOfPreviousTradingDaysOverWhichMedianDailyDollarTradingVolumeIsConsidered" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentRedemptionTriggerMinimumPercentageByWhichClosingTradePriceExceedsNasdaqMinimumPriceConsidered" id="nrxp_DebtInstrumentRedemptionTriggerMinimumPercentageByWhichClosingTradePriceExceedsNasdaqMinimumPriceConsidered" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentRedemptionTriggerNumberOfFollowingTradingDaysOverWhichClosingTradePriceIsConsidered" id="nrxp_DebtInstrumentRedemptionTriggerNumberOfFollowingTradingDaysOverWhichClosingTradePriceIsConsidered" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentMonthlyRedemptionAmount" id="nrxp_DebtInstrumentMonthlyRedemptionAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="MaximumPercentageOfCommonStockOutstanding" id="nrxp_MaximumPercentageOfCommonStockOutstanding" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="DebtInstrumentAmountAgreedToPayInCashToAmendRedemptionProvisions" id="nrxp_DebtInstrumentAmountAgreedToPayInCashToAmendRedemptionProvisions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DebtInstrumentMaximumMonthlyRedemptionAmountPerMonth" id="nrxp_DebtInstrumentMaximumMonthlyRedemptionAmountPerMonth" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DebtInstrumentPeriodicPaymentInterestPaidFromIssuanceOfStock" id="nrxp_DebtInstrumentPeriodicPaymentInterestPaidFromIssuanceOfStock" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AggregateNumberOfWarrantsIssued" id="nrxp_AggregateNumberOfWarrantsIssued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DeemedDividendWarrants" id="nrxp_DeemedDividendWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="NetLossAttributableToCommonStockholders" id="nrxp_NetLossAttributableToCommonStockholders" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
</xsd:schema>
