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  <xsd:element abstract="true" id="nrxp_ATMOfferingMember" name="ATMOfferingMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_AccountsReceivableAllowanceForCreditLossIncreaseDecreaseFromAcquisition" name="AccountsReceivableAllowanceForCreditLossIncreaseDecreaseFromAcquisition" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_AccretionOfOperatingLeaseLiability" name="AccretionOfOperatingLeaseLiability" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_AccruedClinicalSiteCostsCurrent" name="AccruedClinicalSiteCostsCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_AccruedLiabilitiesAcquisitionCosts" name="AccruedLiabilitiesAcquisitionCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_AccruedLiabilitiesAndOtherCurrentLiabilities" name="AccruedLiabilitiesAndOtherCurrentLiabilities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_AccruedResearchAndDevelopmentLiabilityCurrent" name="AccruedResearchAndDevelopmentLiabilityCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_AdjustmentsToAdditionalPaidInCapitalAmortizationOfPrepaidOfferingCosts" name="AdjustmentsToAdditionalPaidInCapitalAmortizationOfPrepaidOfferingCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_AlvogenAndLotusWarrantsMember" name="AlvogenAndLotusWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_AlvogenLicensingAgreementMember" name="AlvogenLicensingAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_AmendedAnsonWarrantsMember" name="AmendedAnsonWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_AmortizationOfDeferredOfferingCostsToAdditionalPaidinCapital" name="AmortizationOfDeferredOfferingCostsToAdditionalPaidinCapital" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_AnnualRevenueThresholdMember" name="AnnualRevenueThresholdMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_AnsonConvertibleNotesMember" name="AnsonConvertibleNotesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_AnsonFirstAndThirdTrancheNotesMember" name="AnsonFirstAndThirdTrancheNotesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_AnsonFirstTrancheNotesMember" name="AnsonFirstTrancheNotesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_AnsonNoteMember" name="AnsonNoteMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_AnsonSecondAndThirdTrancheNotesMember" name="AnsonSecondAndThirdTrancheNotesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_AnsonSecondTrancheNotesMember" name="AnsonSecondTrancheNotesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_AnsonThirdTrancheNotesMember" name="AnsonThirdTrancheNotesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_AnsonWarrantsMember" name="AnsonWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_AnsonWarrantsTrancheOneMember" name="AnsonWarrantsTrancheOneMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_AnsonWarrantsTrancheThreeMember" name="AnsonWarrantsTrancheThreeMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_AnsonWarrantsTrancheTwoMember" name="AnsonWarrantsTrancheTwoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_April2024OfferingMember" name="April2024OfferingMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_AprilOverallotmentAgreementMember" name="AprilOverallotmentAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_AprilOverallotmentWarrantsMember" name="AprilOverallotmentWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_AprilUnderwriterAgreementMember" name="AprilUnderwriterAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_AprilUnderwriterWarrantsMember" name="AprilUnderwriterWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_BusinessCombinationExcludedFromPurchasePriceContingentConsiderationTerm" name="BusinessCombinationExcludedFromPurchasePriceContingentConsiderationTerm" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_BusinessCombinationExcludedFromPurchasePriceIssuanceOfShares" name="BusinessCombinationExcludedFromPurchasePriceIssuanceOfShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentFindersFees" name="BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentFindersFees" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_BusinessCombinationRecognizedAssetAcquiredAssetsIncludingGoodwill" name="BusinessCombinationRecognizedAssetAcquiredAssetsIncludingGoodwill" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_BusinessCombinationRecognizedAssetAcquiredRightofuseAsset" name="BusinessCombinationRecognizedAssetAcquiredRightofuseAsset" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_BusinessCombinationRecognizedLiabilityAssumedAccruedSalariesAndBenefits" name="BusinessCombinationRecognizedLiabilityAssumedAccruedSalariesAndBenefits" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_CashCashEquivalentRestrictedCashAndRestrictedCashEquivalentIncludingDiscontinuedOperationNet" name="CashCashEquivalentRestrictedCashAndRestrictedCashEquivalentIncludingDiscontinuedOperationNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="nrxp_ClassAUnitsMember" name="ClassAUnitsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_ClassOfWarrantOfRightGrantDateFairValue" name="ClassOfWarrantOfRightGrantDateFairValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_ClassOfWarrantOrRightBeneficialOwnershipLimitation" name="ClassOfWarrantOrRightBeneficialOwnershipLimitation" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_ClassOfWarrantOrRightExercisePricePercentageOfClosingPrice" name="ClassOfWarrantOrRightExercisePricePercentageOfClosingPrice" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_ClassOfWarrantOrRightExercisedDuringPeriod" name="ClassOfWarrantOrRightExercisedDuringPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_ClassOfWarrantOrRightExercisedWeightedAverageExercisePrice" name="ClassOfWarrantOrRightExercisedWeightedAverageExercisePrice" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_ClassOfWarrantOrRightExercisedWeightedAverageRemainingTerm" name="ClassOfWarrantOrRightExercisedWeightedAverageRemainingTerm" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_ClassOfWarrantOrRightExpiredDuringPeriod" name="ClassOfWarrantOrRightExpiredDuringPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_ClassOfWarrantOrRightFairValueOfWarrantOrRight" name="ClassOfWarrantOrRightFairValueOfWarrantOrRight" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_ClassOfWarrantOrRightIncreaseDecreaseInNumberOfSecuritiesCalledByWarrantsOrRights" name="ClassOfWarrantOrRightIncreaseDecreaseInNumberOfSecuritiesCalledByWarrantsOrRights" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_ClassOfWarrantOrRightIssuedDuringPeriod" name="ClassOfWarrantOrRightIssuedDuringPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_ClassOfWarrantOrRightIssuedInPeriod" name="ClassOfWarrantOrRightIssuedInPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_ClassOfWarrantOrRightIssuedWeightedAverageExercisePrice" name="ClassOfWarrantOrRightIssuedWeightedAverageExercisePrice" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_ClassOfWarrantOrRightIssuedWeightedAverageRemainingTerm" name="ClassOfWarrantOrRightIssuedWeightedAverageRemainingTerm" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_ClassOfWarrantOrRightPercentageTradingVolumeThresholdIfTriggered" name="ClassOfWarrantOrRightPercentageTradingVolumeThresholdIfTriggered" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_ClassOfWarrantOrRightSecuritiesCalledByWarrantsOrRightsPercentageOfPrincipalDividedByVwap" name="ClassOfWarrantOrRightSecuritiesCalledByWarrantsOrRightsPercentageOfPrincipalDividedByVwap" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_ClassOfWarrantOrRightStockPriceTrigger" name="ClassOfWarrantOrRightStockPriceTrigger" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_ClassOfWarrantOrRightWeightedAverageRemainingTerm" name="ClassOfWarrantOrRightWeightedAverageRemainingTerm" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_ClassOfWarrantsOrRightsAggregateIntrinsicValue" name="ClassOfWarrantsOrRightsAggregateIntrinsicValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_ClassOfWarrantsOrRightsWeightedAverageExercisePrice" name="ClassOfWarrantsOrRightsWeightedAverageExercisePrice" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="nrxp_CohenLlcMember" name="CohenLlcMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_CommercialInsuranceMember" name="CommercialInsuranceMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_CommonStockAndWarrantIssuanceMember" name="CommonStockAndWarrantIssuanceMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_ConsentAndWaiverAgreementMember" name="ConsentAndWaiverAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_ConsiderationSharesMember" name="ConsiderationSharesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_ConsiderationWarrantsMember" name="ConsiderationWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_ConsultationAgreementWithDrJonathanJavittMember" name="ConsultationAgreementWithDrJonathanJavittMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_ConsultationAgreementWithZacharyJavittMember" name="ConsultationAgreementWithZacharyJavittMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_ConsultingAgreementAnnualPayment" name="ConsultingAgreementAnnualPayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_ConsultingAgreementMonthlyPayment" name="ConsultingAgreementMonthlyPayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_ConsultingAgreementPerformanceBonusTargetValue" name="ConsultingAgreementPerformanceBonusTargetValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_ContractCosts" name="ContractCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_ConversionOfAccruedInterestIntoCommonStockMember" name="ConversionOfAccruedInterestIntoCommonStockMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_ConversionOfDebtToCommonStockMember" name="ConversionOfDebtToCommonStockMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_ConversionOfPrincipalAndInterestIntoCommonStockMember" name="ConversionOfPrincipalAndInterestIntoCommonStockMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_ConversionOfPrincipalAndInterestIntoConsiderationSharesMember" name="ConversionOfPrincipalAndInterestIntoConsiderationSharesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_ConversionOfPrincipalAndInterestIntoConsiderationWarrantsMember" name="ConversionOfPrincipalAndInterestIntoConsiderationWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_ConversionOfPrincipalIntoCommonStockMember" name="ConversionOfPrincipalIntoCommonStockMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_ConversionOfSeriesAPreferredStockToCommonStockMember" name="ConversionOfSeriesAPreferredStockToCommonStockMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_ConvertibleNotesExceptAnsonNoteMember" name="ConvertibleNotesExceptAnsonNoteMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_DebtInstrumentInterestRateInEventOfDefault" name="DebtInstrumentInterestRateInEventOfDefault" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_DebtInstrumentNumberOfTranches" name="DebtInstrumentNumberOfTranches" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_DebtInstrumentOriginalIssuanceDiscount" name="DebtInstrumentOriginalIssuanceDiscount" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_DebtIssuanceCosts" name="DebtIssuanceCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_DocumentAndEntityInformation" name="DocumentAndEntityInformation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_DuraMedicalMember" name="DuraMedicalMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_DuraSegmentMember" name="DuraSegmentMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_EndOfPhaseIClinicalTrialsOfLicensedProductMember" name="EndOfPhaseIClinicalTrialsOfLicensedProductMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_EndOfPhaseIIClinicalTrialsOfLicensedProductMember" name="EndOfPhaseIIClinicalTrialsOfLicensedProductMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_EndOfPhaseIIIClinicalTrialsOfLicensedProductMember" name="EndOfPhaseIIIClinicalTrialsOfLicensedProductMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_EquityOfferingMaximumOfferingAmount" name="EquityOfferingMaximumOfferingAmount" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="nrxp_ExclusiveLicenseAgreementMember" name="ExclusiveLicenseAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_FairValueAdjustmentOfConvertibleDebt" name="FairValueAdjustmentOfConvertibleDebt" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_FairValueAdjustmentOfConvertibleDebtNet" name="FairValueAdjustmentOfConvertibleDebtNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityConversionToShares" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityConversionToShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityInitialRecognition" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityInitialRecognition" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityWarrantsExercised" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityWarrantsExercised" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_FebruaryOverallotmentOptionMember" name="FebruaryOverallotmentOptionMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_FebruaryUnderwriterWarrantsMember" name="FebruaryUnderwriterWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_FebruaryUnderwritingAgreementMember" name="FebruaryUnderwritingAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_FebruaryWarrantsMember" name="FebruaryWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_FinitelivedIntangibleAssetExpectedAmortizationYearFour" name="FinitelivedIntangibleAssetExpectedAmortizationYearFour" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="nrxp_FirstCommercialSaleOfLicensedProductInEuropeMember" name="FirstCommercialSaleOfLicensedProductInEuropeMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_FirstCommercialSaleOfLicensedProductInUsMember" name="FirstCommercialSaleOfLicensedProductInUsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_FirstRDWarrantsMember" name="FirstRDWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_FortMyersLeaseMember" name="FortMyersLeaseMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_GainLossOnConsiderationSharesAndWarrants" name="GainLossOnConsiderationSharesAndWarrants" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_GainLossOnConvertibleDebtRedemption" name="GainLossOnConvertibleDebtRedemption" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_GainLossOnExerciseOfWarrants" name="GainLossOnExerciseOfWarrants" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_GainLossOnIssuanceOfCommonStock" name="GainLossOnIssuanceOfCommonStock" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_GainLossOnIssuanceOfRegisteredDirectOffering" name="GainLossOnIssuanceOfRegisteredDirectOffering" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_GlytechLicenseAgreementMember" name="GlytechLicenseAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_IncreaseDecreaseInInsuranceLoanPayable" name="IncreaseDecreaseInInsuranceLoanPayable" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_IntangibleAssetMeasurementInput" name="IntangibleAssetMeasurementInput" nillable="true" substitutionGroup="xbrli:item" type="xbrli:decimalItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="nrxp_LeaseContractualTermOfficeSpaceRentalMember" name="LeaseContractualTermOfficeSpaceRentalMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_LeaseExpense" name="LeaseExpense" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_LeasesBalanceSheetDisclosuresTableTextBlock" name="LeasesBalanceSheetDisclosuresTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_LesseeNumberOfOpertingLeases" name="LesseeNumberOfOpertingLeases" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_LesseeOperatingLeaseBaseMonthlyRent" name="LesseeOperatingLeaseBaseMonthlyRent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_LesseeOperatingLeaseCommonAreaMaintenanceFee" name="LesseeOperatingLeaseCommonAreaMaintenanceFee" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_LesseeOperatingLeaseMonthlyBaseRentAnnualEscalation" name="LesseeOperatingLeaseMonthlyBaseRentAnnualEscalation" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_LesseeOperatingLeaseMonthlyTaxes" name="LesseeOperatingLeaseMonthlyTaxes" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_LicenseAgreementCumulativePayments" name="LicenseAgreementCumulativePayments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_LicenseAgreementMaintenanceFee" name="LicenseAgreementMaintenanceFee" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_LicenseAgreementMilestonePayment" name="LicenseAgreementMilestonePayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_LicenseAgreementsMilestonePaymentsConditionalReductionPercentage" name="LicenseAgreementsMilestonePaymentsConditionalReductionPercentage" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_LitigationSettlementPaymentInstallmentOne" name="LitigationSettlementPaymentInstallmentOne" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_LitigationSettlementPaymentInstallmentTwo" name="LitigationSettlementPaymentInstallmentTwo" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_LongtermDebtPrincipalOnly" name="LongtermDebtPrincipalOnly" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="nrxp_MeasurementInputAfterTaxRateOfReturnMember" name="MeasurementInputAfterTaxRateOfReturnMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_MeasurementInputContributoryAssetsChargeMember" name="MeasurementInputContributoryAssetsChargeMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_MeasurementInputDistributorEbitMarginMember" name="MeasurementInputDistributorEbitMarginMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_MeasurementInputIncomeTaxRateMember" name="MeasurementInputIncomeTaxRateMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_MeasurementInputObsolesceMember" name="MeasurementInputObsolesceMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_MeasurementInputReplacementCostGrowthRateMember" name="MeasurementInputReplacementCostGrowthRateMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_MeasurementInputRevenueGrowthRateAfterFy2030Member" name="MeasurementInputRevenueGrowthRateAfterFy2030Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_MeasurementInputRevenueGrowthRateThroughFy20230Member" name="MeasurementInputRevenueGrowthRateThroughFy20230Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_MeasurementInputRoyaltyRateMember" name="MeasurementInputRoyaltyRateMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_MeasurementInputTaxAmortizationPeriodMember" name="MeasurementInputTaxAmortizationPeriodMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_MeasurementInputUsefulLifeMember" name="MeasurementInputUsefulLifeMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_MedicalEquipmentMember" name="MedicalEquipmentMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_MedicareMember" name="MedicareMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_MultiPeriodExcessEarningsMethodMpeemMember" name="MultiPeriodExcessEarningsMethodMpeemMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_NRXPharmaceuticalsIncMember" name="NRXPharmaceuticalsIncMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_NaplesLeaseMember" name="NaplesLeaseMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_NeuroRxMember" name="NeuroRxMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_NondesignatedPreferredStockMember" name="NondesignatedPreferredStockMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_NoteToFinancialStatementDetailsTextual" name="NoteToFinancialStatementDetailsTextual" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_NotesToFinancialStatements" name="NotesToFinancialStatements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_NotesToFinancialStatementsAbstract" name="NotesToFinancialStatementsAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_NrxSegmentMember" name="NrxSegmentMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_OtherLeaseExpense" name="OtherLeaseExpense" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_PatentLicenseMember" name="PatentLicenseMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_PaymentForLicenseAgreementMaintenanceFee" name="PaymentForLicenseAgreementMaintenanceFee" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_PlacementAgentFeePercentOfGrossProceeds" name="PlacementAgentFeePercentOfGrossProceeds" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="nrxp_PolicyTable" name="PolicyTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_PrepaidClinicalDevelopmentExpense" name="PrepaidClinicalDevelopmentExpense" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_PrepaidExpensesAndOtherCurrentAssetsTextBlock" name="PrepaidExpensesAndOtherCurrentAssetsTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_PrivatePlacementPremiumPercentage" name="PrivatePlacementPremiumPercentage" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_PrivatePlacementWarrantsMember" name="PrivatePlacementWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_ProceduresMember" name="ProceduresMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_ProceedsFromInsuranceLoans" name="ProceedsFromInsuranceLoans" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_ProceedsFromIssuanceOfCommonStockAndWarrantsNet" name="ProceedsFromIssuanceOfCommonStockAndWarrantsNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_ProductsCoveredByLicensedPatentsMember" name="ProductsCoveredByLicensedPatentsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_ProductsCoveredByValidClaimsMember" name="ProductsCoveredByValidClaimsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_ProvisionReversalForDoubtfulAccounts" name="ProvisionReversalForDoubtfulAccounts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_PublicWarrantsMember" name="PublicWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_RDPurchaseAgreementMember" name="RDPurchaseAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_ReclassificationOfAccumulatedOtherComprehensiveIncomeUponSettlementOfConvertibleDebt" name="ReclassificationOfAccumulatedOtherComprehensiveIncomeUponSettlementOfConvertibleDebt" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_RegisteredDirectOfferingMember" name="RegisteredDirectOfferingMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_ReliefFromRoyaltyMethodMember" name="ReliefFromRoyaltyMethodMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_RepaymentsOfInsuranceLoans" name="RepaymentsOfInsuranceLoans" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_RisksAndUncertaintiesPolicyTextBlock" name="RisksAndUncertaintiesPolicyTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_RoyaltyPercentage" name="RoyaltyPercentage" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="nrxp_SarahHerzogMemorialHospitalLicenseAgreementMember" name="SarahHerzogMemorialHospitalLicenseAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_ScheduleOfMilestonePaymentsTableTextBlock" name="ScheduleOfMilestonePaymentsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_SeriesAConvertiblePreferredStockMember" name="SeriesAConvertiblePreferredStockMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_SharebasedCompensationArrangementBySharebasedPaymentAwardAnnualPercentageIncreaseInAuthorizedShares" name="SharebasedCompensationArrangementBySharebasedPaymentAwardAnnualPercentageIncreaseInAuthorizedShares" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element id="nrxp_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodGrantDateFairValue" name="SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodGrantDateFairValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsGrantsInPeriodGrantDateFairValue" name="SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsGrantsInPeriodGrantDateFairValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsGrantsInPeriodWeightedAverageRemainingContractualTerm" name="SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsGrantsInPeriodWeightedAverageRemainingContractualTerm" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_StockIssuanceToVendorMember" name="StockIssuanceToVendorMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_StockIssuedAsOfferingCosts" name="StockIssuedAsOfferingCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_StockIssuedDuringPeriodSharesSharesIssuedFromRepricing" name="StockIssuedDuringPeriodSharesSharesIssuedFromRepricing" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_StockIssuedDuringPeriodSharesWarrantsExercised" name="StockIssuedDuringPeriodSharesWarrantsExercised" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_StockIssuedDuringPeriodValueSharesIssuedFromRepricing" name="StockIssuedDuringPeriodValueSharesIssuedFromRepricing" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_StockIssuedDuringPeriodValueWarrantsExercised" name="StockIssuedDuringPeriodValueWarrantsExercised" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_StockSubscriptionsReceivableWriteOff" name="StockSubscriptionsReceivableWriteOff" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_StreetervileComplaintMember" name="StreetervileComplaintMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_StreetervilleConvertibleNoteMember" name="StreetervilleConvertibleNoteMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_SubscriptionReceivableCurrent" name="SubscriptionReceivableCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="nrxp_SubstituteWarrantsMember" name="SubstituteWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_The2016OmnibusIncentivePlanMember" name="The2016OmnibusIncentivePlanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_The2021OmnibusIncentivePlanMember" name="The2021OmnibusIncentivePlanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_TherapyMember" name="TherapyMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_ThirdTrancheNotesMember" name="ThirdTrancheNotesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_ThirdTrancheNotesWarrantsMember" name="ThirdTrancheNotesWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_UnderwriterOverallotmentWarrantsMember" name="UnderwriterOverallotmentWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_WarrantsExercisedNoncash" name="WarrantsExercisedNoncash" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_WarrantsExercisedSubscriptionReceivable" name="WarrantsExercisedSubscriptionReceivable" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="nrxp_WarrantsIssuedForAlvogenAgreementAmendmentMember" name="WarrantsIssuedForAlvogenAgreementAmendmentMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_WarrantsMember" name="WarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_WarrantsOtherThanConsiderationWarrantsMember" name="WarrantsOtherThanConsiderationWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_WithAndWithoutMethodMember" name="WithAndWithoutMethodMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="nrxp_WorkingCapitalDeficit" name="WorkingCapitalDeficit" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-11-commitments-and-contingencies-schedule-of-milestone-payments-details" name="statement-statement-note-11-commitments-and-contingencies-schedule-of-milestone-payments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-11-commitments-and-contingencies-tables" name="statement-statement-note-11-commitments-and-contingencies-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-12-equity-schedule-of-warrants-details" name="statement-statement-note-12-equity-schedule-of-warrants-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-12-equity-tables" name="statement-statement-note-12-equity-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-13-stockbased-compensation-schedule-of-restricted-stock-awards-details" name="statement-statement-note-13-stockbased-compensation-schedule-of-restricted-stock-awards-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-13-stockbased-compensation-schedule-of-stock-options-details" name="statement-statement-note-13-stockbased-compensation-schedule-of-stock-options-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-13-stockbased-compensation-schedule-of-stockbased-compensation-details" name="statement-statement-note-13-stockbased-compensation-schedule-of-stockbased-compensation-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-13-stockbased-compensation-tables" name="statement-statement-note-13-stockbased-compensation-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-14-fair-value-measurements-schedule-of-assets-and-liabilities-on-a-recurring-basis-details" name="statement-statement-note-14-fair-value-measurements-schedule-of-assets-and-liabilities-on-a-recurring-basis-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-14-fair-value-measurements-schedule-of-nonrecurring-level-3-fair-value-measurements-details" name="statement-statement-note-14-fair-value-measurements-schedule-of-nonrecurring-level-3-fair-value-measurements-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-14-fair-value-measurements-schedule-of-recurring-level-3-fair-value-changes-details" name="statement-statement-note-14-fair-value-measurements-schedule-of-recurring-level-3-fair-value-changes-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-14-fair-value-measurements-schedule-of-significant-inputs-details" name="statement-statement-note-14-fair-value-measurements-schedule-of-significant-inputs-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-14-fair-value-measurements-tables" name="statement-statement-note-14-fair-value-measurements-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-15-segment-reporting-longlived-assets-details" name="statement-statement-note-15-segment-reporting-longlived-assets-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-15-segment-reporting-reconciliation-of-loss-from-operations-to-total-loss-details" name="statement-statement-note-15-segment-reporting-reconciliation-of-loss-from-operations-to-total-loss-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-15-segment-reporting-tables" name="statement-statement-note-15-segment-reporting-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-17-business-acquisition-acquired-intangible-assets-details" name="statement-statement-note-17-business-acquisition-acquired-intangible-assets-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-17-business-acquisition-assets-acquired-and-liabilities-assumed-details" name="statement-statement-note-17-business-acquisition-assets-acquired-and-liabilities-assumed-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-17-business-acquisition-pro-forma-details" name="statement-statement-note-17-business-acquisition-pro-forma-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-17-business-acquisition-tables" name="statement-statement-note-17-business-acquisition-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-3-summary-of-significant-accounting-policies-schedule-of-antidilutive-securities-details" name="statement-statement-note-3-summary-of-significant-accounting-policies-schedule-of-antidilutive-securities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-3-summary-of-significant-accounting-policies-tables" name="statement-statement-note-3-summary-of-significant-accounting-policies-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-4-revenue-allowance-for-credit-loss-details" name="statement-statement-note-4-revenue-allowance-for-credit-loss-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-4-revenue-disaggregation-of-revenue-details" name="statement-statement-note-4-revenue-disaggregation-of-revenue-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-4-revenue-schedule-of-accounts-receivable-details" name="statement-statement-note-4-revenue-schedule-of-accounts-receivable-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-4-revenue-tables" name="statement-statement-note-4-revenue-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-5-prepaid-expense-and-other-current-assets-schedule-of-prepaid-expense-and-other-current-assets-details" name="statement-statement-note-5-prepaid-expense-and-other-current-assets-schedule-of-prepaid-expense-and-other-current-assets-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-5-prepaid-expense-and-other-current-assets-tables" name="statement-statement-note-5-prepaid-expense-and-other-current-assets-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-6-furniture-and-equipment-net-furniture-and-equipment-details" name="statement-statement-note-6-furniture-and-equipment-net-furniture-and-equipment-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-6-furniture-and-equipment-net-tables" name="statement-statement-note-6-furniture-and-equipment-net-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-7-leases-balance-sheet-disclosures-details" name="statement-statement-note-7-leases-balance-sheet-disclosures-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-7-leases-components-of-lease-expense-details" name="statement-statement-note-7-leases-components-of-lease-expense-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-7-leases-schedule-of-minimum-lease-payments-details" name="statement-statement-note-7-leases-schedule-of-minimum-lease-payments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-7-leases-tables" name="statement-statement-note-7-leases-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-8-accrued-and-other-current-liabilities-schedule-of-accrued-and-other-current-liabilities-details" name="statement-statement-note-8-accrued-and-other-current-liabilities-schedule-of-accrued-and-other-current-liabilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-note-8-accrued-and-other-current-liabilities-tables" name="statement-statement-note-8-accrued-and-other-current-liabilities-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nrxp_statement-statement-significant-accounting-policies-policies" name="statement-statement-significant-accounting-policies-policies" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
</xsd:schema>
